Featured Publications

Single-cell, multi-region profiling of the macaque brain across the lifespan

Yang X, Watkins KL, DeCasien AR, O’Neill MB, Bohlen MO, O’Day DR, Duran M, Qiu C, Meleshko A, Vo A, Menke M, Calderon D, Cayo Biobank Research Unit, Sallet J, Higham JP, Martínez MI, Trapnell C, Starita LM, Montague MJ, Platt ML**, Chiou KL**, Shendure J**, Snyder-Mackler N**.

bioRxiv (2025) DOI: 10.1101/2025.10.31.685880

How and why does aging occur? Updating evolutionary theory to meet a new era of data

Metcalf CJE**, Anderson RM, Hochberg ME, Masel J, Moorad J, Promislow DEL, Tuljapurkar S, Snyder-Mackler N**.

Evolution, Medicine, and Public Health (2026) DOI: 10.1093/emph/eoaf040

Age and early life adversity shape heterogeneity of the epigenome across tissues in macaques Sadoughi B*, Petersen R*, Patterson SK, Slikas E, Adjandba C, Ryan N, Costa CE, Newman LE, Watowich MM, Kelsey CR, Greenier A, Goldman EA, Negrón-Del Valle JE, Phillips D, Thompson I, Bauman Surratt SE, González O, Compo N, Burgos A, Cayo Biobank Research Unit, DeCasien AR, Chiou KL, Walker CS, Ruiz Lambides AV, Martínez MI, Sterner KN, Brent LJN, Higham JP, Montague MJ, Platt ML, Snyder-Mackler N**, Lea AJ** bioRxiv (2025) DOI: 10.1101/2025.07.13.664445

Non-invasive measures of DNA methylation capture molecular aging in wild capuchin monkeys

Sadoughi B, Hernández-Rojas R, Hamou H, Lopez R, Mah M, Slikas E, Simmons SMV, Orkin JD, Higham JP, Brosnan SF, Jack KM, Campos FA, Snyder-Mackler N**, Melin AD**

bioRxiv (2025) DOI: 10.1101/2025.06.03.657357

Genetic Architecture of Immune Cell DNA Methylation in the Rhesus Macaque

Costa CE, Watowich MM, Goldman EA, Sterner KN, Negron-Del Valle JE, Phillips D, Cayo Biobank Research Unit, Platt ML, Montague MJ, Brent LJN, Higham JP, Snyder-Mackler N**, Lea AJ**.

Molecular Ecology (2024) DOI: 10.1111/mec.17576

Aging at scale: Younger dogs and larger breeds from the Dog Aging Project show accelerated epigenetic aging

McCoy BM, Mariner BL, Cheng CF, Slikas E, Adjangba C, Greenier A, Brassington L, Marye A, Harrison BR, Partida-Aguilar M, Bamberger T, Algavi Y, Muller E, Harris A, Rout E, The Dog Aging Project Consortium, Avery A, Borenstein E, Promislow D, Snyder-Mackler N**.

bioRxiv (2024) DOI: 10.1101/2024.10.03.616519

DNA methylation of transposons pattern aging across a diverse cohort of dogs from the Dog Aging Project

Mariner BL, McCoy BM, Greenier A, Brassington L, Slikas E, Adjangba C, Cheng CF, Marye A, Harrison BR, Partida-Aguilar M, Bamberger T, Algavi Y, Muller E, Harris A, Rout E, Dog Aging Project Consortium, Avery A, Promislow D, Borenstein E, Snyder-Mackler N**.

bioRxiv (2024) DOI: 10.1101/2024.10.08.617286

Immune gene regulation is associated with age and environmental adversity in a wild primate

Watowich MM, Costa CE, Chiou KL, Goldman EA, Petersen RM, Patterson S, Cayo Biobank Research Unit, Martínez MI, Sterner KN, Horvath JE, Montague MJ, Platt ML, Brent LJN, Higham JP, Lea AJ**, Snyder-Mackler N**.

Molecular Ecology (2024) DOI: 10.1111/mec.17445

Immune cell composition varies by age, sex and exposure to social adversity in free-ranging rhesus macaques

Sanchez Rosado MR, Marzan-Rivera N, Watowich MM, Negron-Del Valle AD, Pantoja P, Pavez-Fox MA, Siracusa ER, Cooper EB, Negron-Del Valle JE, Phillips D, Ruiz-Lambides A, Cayo Biobank Research Unit, Martinez MI, Montague MJ, Platt ML, Higham JP, Brent LJN, Sariol CA, Snyder-Mackler N**.

GeroScience (2024) DOI: 10.1007/s11357-023-00962-8